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June 18, 2026International Journal of Applied and Basic Medical ResearchOpen Access

Association of Melanocortin-4 Receptor Single Nucleotide Polymorphisms rs2331841 and rs12970134 with Metabolically Unhealthy Obesity in a North Indian Cohort

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Authors

ISIsar SharmaUniversity of JammuKBKritika BakshiUniversity of JammuRMRitu MahajanUniversity of Jammu

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Implication

Randomized trial investigates MC4R genetic variations linked to metabolically unhealthy obesity in North Indian adults, suggesting implications for early risk assessment.

Key Points

  • This study aimed to explore the genetic basis behind metabolically unhealthy obesity (MUHO) focusing on MC4R gene variations.
  • Analyzed 846 adult participants from Jammu, categorized into MUHO, MHO, and MH-NW groups.
  • Performed genotyping to assess the association of MC4R SNPs rs2331841 and rs12970134.
  • The 'A' allele of rs2331841 was linked to a 1.75-fold increased risk for MUHO compared to MH-NW (P = 0.0008).
  • The 'A' allele of rs12970134 showed a 1.60-fold increased risk for MUHO versus MH-NW (P = 0.005).

Cite This Study

Sharma et al. (2026) studied this question.

synapsesocial.com/papers/6a338cf6630953a74978e055https://doi.org/10.4103/ijabmr.ijabmr_408_25
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  3. 3Metabolically Healthy and Unhealthy Normal Weight and Obesity2020 · 90 citations