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November 1, 2025Veterinary Medicine and ScienceOpen Access

Impact of Cryopreservation Extenders on Epigenetic Changes in Bull Sperm: H19 and MEG3 Methylation

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Authors

RFRazieh FouladvandiAMAli Akbar MasoudiMSMohsen Sharafi

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Overview

This study demonstrates the impact of cryopreservation extenders on sperm quality and DNA methylation in bulls, pointing to considerations for future fertility research.

Key Points

  • This research investigates how cryopreservation affects bull sperm quality and epigenetic changes related to methylation.
  • Compared effects of soy lecithin and egg yolk extenders on sperm quality and methylation levels.
  • Evaluated sperm motility, membrane integrity, and morphology using bull sperm samples.
  • Analyzed DNA methylation levels of H19 and MEG3 genes through bisulphite sequencing.
  • Total motility decreased significantly after cryopreservation with both extenders.
  • SLE extender showed better preservation of motility and membrane integrity compared to EYE.
  • No significant differences in methylation levels of H19 and MEG3 genes between the two extenders.

Cite This Study

Fouladvandi et al. (2025) studied this question.

synapsesocial.com/papers/69254377c0ce034ddc358cd2https://doi.org/10.1002/vms3.70688
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of different extenders on epigenetic patterns and functional parameters of bull sperm during cryopreservation process2024 · 1 citations
  2. 2Epididymosome‐Supplemented Extender Induces Changes in Morpho‐Functional Traits and microRNA Levels of Post‐Thaw Sperm and Improves Embryo Developmental Potential2026
  3. 3Effects of Type of Extender and Freezing Method on Bovine Semen Post‐Thawed Quality Characteristics and Bacterial Contamination2026
  4. 4Potential use of soy lecithin or butylated hydroxytoluene as an alternative to powdered egg yolk for ram semen cryopreservation2024
  5. 5Cryopreservation of stallion sperm in different extenders2025