The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus

This study aimed to evaluate the efficacy of 0.2% topical hyaluronic acid in the management of symptomatic oral lichen planus (OLP). This prospective interventional study was conducted at the Department of Dermatology, Services Institute of Medical Sciences / Services Hospital, Lahore, Pakistan. Fourteen patients with symptomatic OLP lesions applied hyaluronic acid in orabase gel for 28 days. Patients were followed up weekly, and the final assessment was performed at the end of four weeks. The baseline mean modified oral mucositis index (MOMI) score decreased from 2.06 ± 0.41 to 0.27 ± 0.34 for cheek lesions and from 1.50 ± 00 to 0.25 ± 0.25 for lip lesions. The mean change in MOMI score for cheek was 1.79 ± 0.40 and for lips was 1.25 ± 0.25. These findings suggest that topical hyaluronic acid 0.2% is effective in the treatment of symptomatic OLP and can be easily and safely used as an adjuvant treatment alongside other topical and systemic treatments.