Radiotherapy dose–response of mycosis fungoides with large cell transformation

Martin Higgins; Philippa Johnstone; H. Miles Prince; Stephen Lade; Michael T. Fahey; Chris McCormack; Carrie van der Weyden; Friyana Bhabha; Odette Buelens; Belinda A. Campbell; Martin Higgins; Philippa Johnstone; H. Miles Prince; Stephen Lade; Michael T. Fahey; Chris McCormack; Carrie van der Weyden; Friyana Bhabha; Odette Buelens; Belinda A. Campbell

doi:10.1016/j.radonc.2025.111292

Key Points

This research investigates the dose-response relationship of radiotherapy in mycosis fungoides with large cell transformation.
Assessed treatment response based on radiotherapy dose levels.
Measured overall response rates (ORR) and complete response (CR) rates for varying dosages of EQD2.
Evaluated control efficacy using RT-alone for unifocal cutaneous LCTMF.
EQD2 >12.0 Gy was associated with a 100% overall response rate.
Higher doses (EQD2 >36.0 Gy) achieved a 100% complete response rate.
RT-alone demonstrated excellent infield control and possible curative outcomes for some patients.

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Implication

Observational study finds 100% overall response rate in mycosis fungoides with 36 Gy radiotherapy, suggesting promising curative potential.

Abstract

LCTMF is radio-responsive, with EQD2 >12.0 Gy associated with 100 % ORR. Dose-response was observed, with EQD2 >36.0 Gy achieving 100 % CR rate. For unifocal cutaneous LCTMF, RT-alone achieved excellent infield control with possible curative potential in a proportion of patients.

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Cite This Study

Higgins et al. (2025) studied this question.

synapsesocial.com/papers/69254f7dc0ce034ddc3591e5 https://doi.org/10.1016/j.radonc.2025.111292

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Radiotherapy dose–response of mycosis fungoides with large cell transformation

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Radiotherapy dose–response of mycosis fungoides with large cell transformation

Key Points

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Implication

Abstract

Discussion

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