Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2026HaematologicaOpen Access

Final results of UK NCRI phase II trial of pembrolizumab and radiotherapy in cutaneous T cell lymphoma

View Full Paper
Ask AI
Bookmark
Share

Authors

TITimothy IllidgeWWWilliam WilsonJPJames Paterson

Discussion

Loading...

Member takes

Overview

Randomized trial investigates pembrolizumab's efficacy with radiotherapy in advanced cutaneous T-cell lymphoma, suggesting new treatment options.

Key Points

  • This trial aimed to evaluate the efficacy of pembrolizumab with radiotherapy in patients with advanced cutaneous T-cell lymphoma.
  • Single-arm multicentre phase II trial enrolled 46 relapsed/refractory CTCL patients, median age 63.
  • Patients received pembrolizumab followed by 12Gy radiotherapy to localized lesions in 3 fractions.
  • Primary endpoint was overall response rate, with secondary endpoints including overall survival and progression-free survival.
  • Overall response rate was 24% with 57% of patients still receiving treatment after 1 year.
  • Median follow-up duration was 24.8 months, indicating sustained response efforts.
  • Patients included 41 with mycosis fungoides and 5 with Sézary syndrome, with 24% at stage IV.

Cite This Study

Illidge et al. (2026) studied this question.

synapsesocial.com/papers/6a65a306d3aea3239cd765a1https://doi.org/10.3324/haematol.2025.288878
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skin-directed radiotherapy for primary cutaneous T-cell lymphomas2024
  2. 2Outcomes and toxicity of concomitant radioimmunotherapy following PD-1 blockade for locally advanced and metastatic cutaneous squamous cell carcinoma2025
  3. 3A randomized phase II clinical trial of stereotactic body radiation therapy (SBRT) and systemic pembrolizumab with or without intratumoral avelumab/ipilimumab plus CD1c (BDCA-1)+/CD141 (BDCA-3)+ myeloid dendritic cells in solid tumors2024 · 12 citations
  4. 4Mogamulizumab and Concomitant Hypofractionated Low-Dose Total Skin Electron Beam Therapy (2 × 4 Gy) in Cutaneous T-Cell Lymphoma: Proof of Principle, Report of Two Cases2024 · 7 citations
  5. 5Phase II study of combination of radiotherapy with pembrolizumab plus chemotherapy in patients with previously untreated metastatic non-small cell lung cancer: North Japan Lung Cancer Study Group 1902.2024 · 1 citations