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November 1, 2025The Journal of ImmunologyOpen Access

Suppression of IFN-γ expression in Treg cells is dependent on the TCR signaling pathway 2137

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Authors

THTianyun HuaYZYe ZhengYLYuqiong Liang

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Overview

Genome-wide screen identifies Treg cell mechanisms affecting IFN-γ expression and tumor prognosis, suggesting therapeutic targets.

Key Points

  • To understand the molecular mechanisms by which Treg cells suppress IFN-γ expression and their implications in tumor prognosis.
  • Conducted a genome-wide CRISPR/Cas9 screen to identify genes related to IFN-γ suppression in Treg cells.
  • Targeted ablation of ZAP70 and other TCR signaling pathway genes to measure effects on IFN-γ expression.
  • Utilized an adoptive T cell transfer tumor model to evaluate the effects of gene ablation on tumor size.
  • Identified ZAP70 as a critical component involved in the suppression of IFN-γ expression in Treg cells.
  • Ablation of ZAP70 led to increased IFN-γ expression while maintaining Foxp3 levels in Treg cells.
  • Reduction in tumor size observed in mice given ZAP70-deficient Tregs, indicating enhanced anti-tumor response.

Cite This Study

Hua et al. (2025) studied this question.

synapsesocial.com/papers/69254f89c0ce034ddc35976ehttps://doi.org/10.1093/jimmun/vkaf283.099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Suppression of IFN-g expression in Treg cells is dependent on the TCR signaling pathway 23329352026
  2. 2Treg-derived IFN-γ supports the differentiation of Th1-Treg in tumor immunity and autoimmunity2026 · 1 citations
  3. 3Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments2026
  4. 4Regulatory T cells sabotage antitumor γδ T cells by creating IL-2-deficient environments2025 · 2 citations
  5. 5Abstract 723: Reduction of immunosuppressive function of regulatory T cells enhances antigen-specific T cell mediated cytotoxicity against tumor cells2024