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November 1, 2025The Journal of ImmunologyOpen Access

IRF5 is required for inflammatory hemophagocyte differentiation and disease development in TLR7-mediated Macrophage Activation Syndrome 4643

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Authors

NTNatalie K ThulinALAiling LuSOSusana L Orozco

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Overview

This study shows IRF5 is essential for hemophagocytosis and disease in mice with Macrophage Activation Syndrome, implying it may be a therapeutic target.

Key Points

  • The research aims to determine the role of IRF5 in hemophagocyte differentiation and development of Macrophage Activation Syndrome (MAS).
  • Utilized TLR7.1 mouse model to investigate MAS
  • Examined differentiation of inflammatory hemophagocytes from Ly6CHI monocytes
  • Performed paired RNA-seq and ATAC-seq to analyze IRF5 signaling
  • IRF5 signaling is required for inflammatory hemophagocyte differentiation
  • Hemophagocytosis was dependent on myeloid cell IRF5
  • The role of IRF5 was established in both acute and chronic models of MAS

Cite This Study

Thulin et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3597d6https://doi.org/10.1093/jimmun/vkaf283.2296
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IRF5 is required for iHPC differentiation in a mouse model of TLR7-driven macrophage activation syndrome and inhibition of IRF5 activity rescues from disease severity 36042025
  2. 2GM-CSF-IRF5 Axis as a Therapeutic Target in TLR7-Mediated Macrophage Activation Syndrome 23091922026
  3. 3IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans2016 · 66 citations
  4. 4Identification of miRNAs that target Fcγ receptor-mediated phagocytosis during macrophage activation syndrome2024 · 7 citations
  5. 5Liver type 1 innate lymphoid cells undergo apoptosis in murine models of macrophage activation syndrome and are dispensable for disease2024 · 6 citations