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November 1, 2025The Journal of ImmunologyOpen Access

Effects of Moderate Malnutrition during Pregnancy on Neonatal Immunity to Malaria 2369

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Authors

RORobert Sifa Onjiko

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Overview

Experiments reveal malnutrition alters immune responses in neonatal mice infected with Plasmodium, indicating potential risks.

Key Points

  • This research aims to understand the impact of moderate malnutrition during pregnancy on neonatal immunity to malaria.
  • Utilized a young rodent model to investigate immunity in moderate malnutrition versus well-nourished pups.
  • Infected 13-day-old mice with Plasmodium chabaudi parasites and assessed lymphocyte activation.
  • Measured cytokine secretion and transcription factor expression in CD4+ T cells.
  • Malnourished pups showed higher proportions of NK cells but lower activation of CD4+ T cells.
  • Increased proportions of CXCR5+ T cells and CD19+ GL7+ B cells in malnourished pups were observed.
  • No significant difference in IFNγ levels between malnourished and well-nourished groups.

Cite This Study

Robert Sifa Onjiko (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3598a2https://doi.org/10.1093/jimmun/vkaf283.295
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Malnutrition on Serum Levels of Pro-inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria2024
  2. 2Leveraging Non-Human Primates to Investigate Malaria Infection and Immunity 44372025
  3. 3Maternal undernutrition in pregnancy and lactation programs impaired immune system development and function in male offspring2026
  4. 4Memory-like NK cells protective roles or lack thereof in uncomplicated and severe malaria 21072025
  5. 5The Impact of Maternal Malaria on Adaptive Immune Responses in Offspring2024