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This research examines how chemotherapy influences the development of pro-metastatic monocytes through progenitor cell modulation.

Modulation of progenitor cells is involved in the development of chemotherapy triggered pro-metastatic monocytes 2568

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Observational study shows chemotherapy increases monocytes in peripheral blood, suggesting progenitor cell modulation influences immunity.

This research examines how chemotherapy influences the development of pro-metastatic monocytes through progenitor cell modulation.
Analyzed peripheral blood samples from breast cancer patients after chemotherapy treatment.
Investigated bone marrow Lin-Sca1+c-Kit+ cells under chemotherapy regimens.
Employed in vivo treatment with mtROS scavenger and β-glucan to assess effects on monocyte yield and phenotype.
Chemotherapy triggers an expansion of monocytes in peripheral blood and tumor tissues.
Mitochondrial ROS production is associated with monocyte development from progenitor cells.
β-glucan treatment reverses chemotherapy-induced pro-metastatic effects.

Ding et al. (2025) studied this question.

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Observational study shows chemotherapy increases monocytes in peripheral blood, suggesting progenitor cell modulation influences immunity.