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This research aims to understand how chemotherapy affects myelopoiesis and the characteristics of resultant immunosuppressive monocytes.

April 10, 2026JCI InsightOpen Access

Chemotherapy-induced reactive myelopoiesis promotes expansion of immunosuppressive neutrophil-like monocytes in mice and humans

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Observations reveal immunosuppressive monocyte expansion in lymphoma patients, indicating potential implications for treatment outcomes.

This research aims to understand how chemotherapy affects myelopoiesis and the characteristics of resultant immunosuppressive monocytes.
Analyzed effects of cyclophosphamide on myelopoiesis in mice and lymphoma patients.
Used single-cell RNA sequencing to examine bone marrow monocytes.
Conducted assays for transposase-accessible chromatin using sequencing (ATAC-seq).
Identified a heterogeneous population of monocytes post-chemotherapy.
Found that chemotherapy induces the expansion of neutrophil-like monocytes (NeuMo).
Discovered that NeuMo exhibits strong T-cell suppressive activity.
Reanalyzed datasets to find similar monocyte populations in chemotherapy-treated cancer patients.

Shi et al. (2026) studied this question.

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