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November 1, 2025The Journal of ImmunologyOpen Access

Centella asiatica extract attenuates on glutamate-induced neurotoxicity in HT22 cells and scopolamine-induced animal model of cognitive impairment 9125

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Authors

YKYun‐Mi KangTKTae In KimJLJae‐Kyoung Lee

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Overview

Study demonstrates that Centella asiatica extract improves cognitive function in mice, indicating neuroprotective effects against oxidative stress.

Key Points

  • This research investigates the neuroprotective effects of Centella asiatica extract on cognitive impairment and neurotoxicity.
  • In vitro studies used HT22 cells to assess glutamate-induced neurotoxicity
  • In vivo studies involved scopolamine-induced cognitive decline in mice
  • Biochemical analyses measured levels of acetylcholine and oxidative stress markers
  • Centella asiatica extract reduced oxidative stress and neuronal apoptosis in HT22 cells
  • Significant improvement in cognitive deficits in mice was observed
  • Increased levels of acetylcholine and enhanced antioxidant enzyme activity were found in the hippocampus

Cite This Study

Kang et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc359945https://doi.org/10.1093/jimmun/vkaf283.2569
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Centella asiatica ameliorates scopolamine-induced cognitive impairment via acetylcholinesterase modulation and oxidative stress reduction2026
  2. 2A review of neuroprotective properties of <i>Centella asiatica</i> (L.) Urb. and its therapeutic effects2025
  3. 3Centella asiatica suppresses inflammation and apoptosis and regulates the Gsk-3β signaling pathway in aluminum chloride-induced neurodegeneration in rats2026
  4. 4Cognitive-Enhancing Effects of Hesperetin-Rich CNE against Neuronal Damage and Memory Impairment by Regulating AKT/Nrf2 and BDNF/CREB Signaling2026
  5. 5Integrative network pharmacology, transcriptomics, and molecular docking identify candidate Centella asiatica constituents and targets in neurodegenerative diseases2026