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November 1, 2025The Journal of ImmunologyOpen Access

Cytotoxic bystander activation of endogenous CAR-negative T cells in response to CD19-CAR T cell therapy 3836

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Authors

JQJia-Hua QuDLDeanna LangfittCCChing-Heng Chou

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Overview

Analysis uncovers roles of endogenous T cells in CAR therapy for acute lymphoblastic leukemia, suggesting implications for treatment outcomes.

Key Points

  • To characterize the role of CAR-negative T cells during CD19-CAR T cell therapy.
  • Analyzed blood and bone marrow samples from 15 pediatric patients post-infusion
  • Employed single-cell gene expression and T cell receptor sequencing
  • Focused on the expansion and contraction phases of CAR T cell therapy.
  • Identified populations of CAR-negative T cells with cytotoxic bystander activation
  • Found greater clonal expansions among CD8+ bystander T cells
  • Determined enduring expansions of structurally similar TCRs indicative of epitope specificity.

Cite This Study

Qu et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc359958https://doi.org/10.1093/jimmun/vkaf283.1591
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1B-cell–directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates2024 · 22 citations
  2. 2Abstract 882: Harnessing single cell multi-omics data to identify predictors of clinical outcome in CD19 CAR T cell therapy2024
  3. 3Abstract 4002: Investigating CAR-T cell efficacy and activation in the disseminated NALM6-luc human B-cell acute lymphoblastic leukemia model2024
  4. 4CAR-T TEMRA and CAR-Tregs in vivo expansion are both associated with a poor response after CD19.CAR-T therapy2026
  5. 5CAR-T efficacy in large B-cell lymphoma is shaped by neoantigen-driven epitope spreading and limited by HLA loss and genomic instability2025 · 1 citations