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November 1, 2025The Journal of ImmunologyOpen Access

Two doses of venom from Bothrops jararaca and Bothrops atrox emitted cytokines and mast cells activation in the peritoneal fluid of C57BL/6 mice 9220

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Authors

ARAdriana da Silva Fernandes Ribas

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Overview

Cytokines released from Bothrops jararaca and Bothrops atrox venoms cause inflammation in C57BL/6 mice, indicating the importance of antivenoms.

Key Points

  • This research aims to understand the inflammatory effects of Bothrops snake venoms on immune responses in mice.
  • Bothrops jararaca and Bothrops atrox venoms were injected into female C57BL/6 mice.
  • Cytokine levels (TNF-a, IL-6, MCP-1, IL-10) were measured using flow cytometry and ELISA.
  • The study focused on mast cell activation and peritoneal fluid analysis.
  • Both venoms significantly increased pro-inflammatory cytokines including TNF-a and IL-6.
  • Bothrops atrox showed higher TNF-a and IL-6 levels compared to Bothrops jararaca.
  • Elevated IL-10 levels indicated a regulatory immune response amid intense inflammation.

Cite This Study

Adriana da Silva Fernandes Ribas (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3599d1https://doi.org/10.1093/jimmun/vkaf283.2649
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