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November 1, 2025Seminars in Nuclear MedicineOpen Access

Sentinel Node Mapping in Penile Cancer: An Update on Methods and Pitfalls

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Authors

CMChristian Arvei MoenJJJakob Kristian Jakobsen

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Overview

Review shows management strategies and innovations in sentinel node mapping for penile cancer, indicating potential for improved outcomes.

Key Points

  • The review aims to update techniques and address pitfalls in sentinel node mapping for penile cancer.
  • Review of dynamic sentinel node biopsy techniques
  • Comparison of imaging methods and their accuracy
  • Discussion of multidisciplinary management and local practice variations
  • Analysis of innovations in tracers and ctDNA applications
  • Dynamic sentinel node biopsy remains the gold standard for staging
  • False-negative rates reported between 12%-13%
  • Less than 20% of patients with metastatic nodes have further metastases after ILND
  • Current guidelines may result in overtreatment for over 80% of cases

Cite This Study

Moen et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3599d3https://doi.org/10.1053/j.semnuclmed.2025.10.001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The surgical technique and protocol for dynamic sentinel node biopsy for penile cancer at a Southeast Asian regional hospital2024 · 1 citations
  2. 2Optimizing Inguinal Lymph Node Dissection for Penile Cancer: A Pathway to Improve Outcomes and Complications—A Narrative Review2025 · 4 citations
  3. 3Long-Term Follow-Up of the Reliability, Accuracy, and Morbidity of Dynamic Sentinel Lymph Node Biopsy in Patients with Intermediate- and High-Risk Penile Cancer and Clinically Negative Lymph Node Status2026
  4. 4Penile cancer: ESMO–EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up2024 · 45 citations
  5. 5(401) Magnetic Sentinel Node Biopsy with Sienna+®/SentiMag® in Penile Squamous Cell Carcinoma: A Feasible Radiation-Free Alternative2026