What does this research mean for the field?

Dynamic sentinel lymph node biopsy is a safe and reliable staging procedure with high sensitivity and low morbidity for patients with clinically node-negative intermediate- and high-risk penile cancer. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the long-term reliability, diagnostic accuracy, and surgical morbidity of radioisotope-guided dynamic sentinel lymph node biopsy in patients with intermediate- and high-risk, clinically node-negative penile cancer.

August 22, 2026Journal of Clinical MedicineOpen Access

Long-Term Follow-Up of the Reliability, Accuracy, and Morbidity of Dynamic Sentinel Lymph Node Biopsy in Patients with Intermediate- and High-Risk Penile Cancer and Clinically Negative Lymph Node Status

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Authors

ÁPÁkos PytelUniversity of Pecs BPBence PytelUniversity of Pecs DSDávid SemjénUniversity of Pecs

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Implication

Cohort study reveals high diagnostic accuracy and low complication rates for dynamic sentinel lymph node biopsy in penile cancer, indicating its reliability as a staging tool.

Key Points

To evaluate the long-term reliability, diagnostic accuracy, and surgical morbidity of radioisotope-guided dynamic sentinel lymph node biopsy in patients with intermediate- and high-risk, clinically node-negative penile cancer.
Retrospective single-center study analyzing 209 patients with intermediate- and high-risk penile cancer and clinically negative lymph nodes who underwent radioisotope-guided dynamic sentinel lymph node biopsy (DSNB) between 2005 and 2024.
Excluded patients with Tis, T1a, or G1 tumors and those with less than 24 months of follow-up.
Evaluated sentinel lymph node yield, histopathology, post-procedure complications, inguinal progression, and false-negative rates.
A total of 573 sentinel lymph nodes were removed (median 2.7 nodes per patient), detecting metastases in 31 patients across 37 groins.
DSNB demonstrated a sensitivity of 91.0% per patient and 92.5% per groin, with false-negative rates of 8.0% and 7.5%, respectively; all false-negative recurrences manifested within two years.
Complications developed in 11.4% of patients (n=24), with the majority being mild to moderate and managed on an outpatient basis; only two patients required surgery and one required readmission.

Cite This Study

Pytel et al. (2026) studied this question.

synapsesocial.com/papers/6a895facca7ade938187e6cf https://doi.org/10.3390/jcm15166449

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Implication

Cohort study reveals high diagnostic accuracy and low complication rates for dynamic sentinel lymph node biopsy in penile cancer, indicating its reliability as a staging tool.

Long-Term Follow-Up of the Reliability, Accuracy, and Morbidity of Dynamic Sentinel Lymph Node Biopsy in Patients with Intermediate- and High-Risk Penile Cancer and Clinically Negative Lymph Node Status

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Key Points

Cite This Study

Long-Term Follow-Up of the Reliability, Accuracy, and Morbidity of Dynamic Sentinel Lymph Node Biopsy in Patients with Intermediate- and High-Risk Penile Cancer and Clinically Negative Lymph Node Status

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Implication

Key Points

Cite This Study

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