Pd-catalyzed sequential distal C–H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams

Perumal Muthuraja; Prabhat Kumar Maharana; Tamilthendral Veerappan; Subhradeep Kar; Tharmalingam Punniyamurthy

doi:10.1039/d5sc08286b

January 1, 2025Chemical ScienceOpen Access

Pd-catalyzed sequential distal C–H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams

View Full Paper

Ask AI

Bookmark

Share

Key Points

Access to macrocyclic lactams is achieved through Pd-catalyzed C–H functionalization and cyclization.
The method generates β-arylated MBH acetates from arylacetic acids.
Palladium( ii )-catalyzed sequential reactions enable novel lactam formation, illustrating potential for diverse applications.
Intramolecular cyclization expands the utility of C–H functionalization in organic synthesis.

Implication

Palladium( ii )-catalyzed functionalization shows access to 14-membered lactams via intramolecular cyclization of MBH acetates.

Abstract

Palladium( ii )-catalyzed meta -C–H functionalization of arylacetic acids with MBH acetates has been accomplished to furnish β-arylated MBH acetates. Further access to 14-membered lactams could be achieved via intramolecular cyclization.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Muthuraja et al. (2025) studied this question.

synapsesocial.com/papers/6925572cc0ce034ddc35a635 https://doi.org/10.1039/d5sc08286b

View Full Paper

Ask AI

Bookmark

Share

Pd-catalyzed sequential distal C–H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams

Key Points

Implication

Abstract

Discussion

Cite This Study

Pd-catalyzed sequential distal C–H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading