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January 1, 2025Chemical Communications

Triphenylphosphonium-based mitochondrial targeting in cancer therapy: mechanisms, progress, and perspectives

Min Yang Jiaming Ou Haibo Yan Yun He LinLing Gan Shao-Lin Zhang Min Yang Jiaming Ou Haibo Yan Yun He Lin-Ling Gan Shao-Lin Zhang

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Key Points

This review aims to summarize the progress and challenges of mitochondrial targeting in cancer therapy.
Reviewing recent literature on triphenylphosphonium-mediated mitochondrial targeting
Analyzing mechanisms of action and therapeutic potential
Discussing emerging opportunities and future perspectives
Identified key challenges in TPP-mediated mitochondrial targeting
Highlighted potential pathways for enhancing anticancer applications
Summarized progress in implementing mitochondrial targeting strategies in therapies

Implication

This review highlights advances in mitochondrial targeting for cancer therapy, suggesting new opportunities for anticancer applications.

Abstract

This review summarizes progress, challenges, and emerging opportunities of TPP-mediated mitochondrial targeting for anticancer applications.

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Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/6925572cc0ce034ddc35a730 https://doi.org/10.1039/d5cc05709d

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