Hybrid Models of Epidemic Waves Including Assessment of Changes in Cellular Receptor Binding Affinity

Purposeful development of special modeling methods for specific modern epidemic situation at accumulation of collective immunity but preservation of mutant pathogen in the population is continued. The evolution of SARS-CoV-2 is not halted by the problem of Long COVID disease chronicization. We propose an evolution of the modeling method to include tracking of the affinity index for ad hoc redefinition of hybrid computational structures according to monitoring of current mutations and estimation of the frequency of strains occurrence.