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January 1, 2025Food & Function

Polyphenols of Ferula lehmanni Boiss. attenuate high-fat diet-induced liver injury by regulating lipid synthesis and remodeling the gut microbiota

Yuting Ye Junlin Ge Wanying He Ping Zhan Danna Wang Peng Wang Honglei Tian Jianshu Liu Yuting Ye Junlin Ge Wanying He Ping Zhan Danna Wang Peng Wang Honglei Tian Jianshu Liu

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Key Points

To investigate the effect of polyphenols from Ferula lehmanni Boiss. on liver injury caused by a high-fat diet.
Conducted an experimental trial using mice on a high-fat diet (HFD)
Administered polyphenols from Ferula lehmanni Boiss. to evaluate their effects
Assessed changes in lipid synthesis and gut microbiota.
Polyphenols reduced liver injury in HFD-induced mice
Significant alterations in gut microbiota composition observed
Improved lipid synthesis markers noted in treated groups.

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Implication

Experiment shows polyphenols improve liver injury in mice on a high-fat diet, indicating changes in gut microbiota.

Abstract

FLBP ameliorates HFD-induced liver injury in mice.

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Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/6925572cc0ce034ddc35a809 https://doi.org/10.1039/d5fo03998c

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