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January 1, 2025Chinese Journal of Cancer Research

Gut microbiota and acute graft-versus-host disease

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Authors

ZCZhile ChenLLLin LiDJDiange Jin

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Overview

Review demonstrates the role of gut microbiota in aGVHD pathology and highlights fecal microbiota transplantation for prophylaxis and treatment.

Key Points

  • This review aims to explore how gut microbiota influences acute graft-versus-host disease and its potential as a therapeutic target.
  • Review of existing literature on gut microbiota and aGVHD
  • Analysis of mechanisms linking dysbiosis to aGVHD pathology
  • Discussion of fecal microbiota transplantation in clinical trials
  • Dysbiosis impacts intestinal barrier integrity and inflammation in aGVHD
  • Microbial metabolites like short-chain fatty acids provide protective effects
  • Specific gut microbial signatures predict aGVHD morbidity and mortality
  • Fecal microbiota transplantation shows efficacy for prevention and treatment of aGVHD

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/69255737c0ce034ddc35aeb5https://doi.org/10.21147/j.issn.1000-9604.2025.05.01
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The gut microbiome in graft-versus-host disease: mechanisms of immune modulation and therapeutic approaches2026
  2. 2Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation2025
  3. 3Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism2024 · 10 citations
  4. 4“The microbiome in graft-versus-host disease: a tale of two ecosystems”2025 · 27 citations
  5. 5Multi-omics analysis of a fecal microbiota transplantation trial identifies novel aspects of acute graft-versus-host disease pathogenesis2024 · 14 citations