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February 21, 2026Gut MicrobesOpen Access

The gut microbiome in graft-versus-host disease: mechanisms of immune modulation and therapeutic approaches

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Authors

AMAdonai Blessington MosesUniversity of WashingtonAYAlbert C. YehCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

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Implication

Review highlights how the gut microbiome influences graft-versus-host disease, suggesting new therapeutic strategies.

Key Points

  • This review examines the role of the gut microbiome in graft-versus-host disease and potential therapies to enhance patient outcomes.
  • Comprehensive literature review of over 40 clinical studies on GvHD and the microbiome.
  • Analysis of the mechanisms by which gut microbes influence immune responses.
  • Evaluation of therapeutic interventions including pre/probiotics and fecal microbiota transplantation.
  • Gut microbiota plays a critical role in initiating and modulating immune responses in GvHD.
  • Therapeutic strategies modifying the microbiome show promise in improving GvHD outcomes.
  • Fecal microbiota transplantation has been highlighted as a key intervention for managing GvHD.

Cite This Study

Moses et al. (2026) studied this question.

synapsesocial.com/papers/69994c01873532290d020368https://doi.org/10.1080/19490976.2026.2631224
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  1. 1Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile2013 · 3,768 citations
  2. 2Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease2023 · 58 citations
  3. 3Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation2012 · 634 citations
  4. 4Microbial metabolite sensor GPR43 controls severity of experimental GVHD2018 · 166 citations
  5. 5Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease2015 · 785 citations