Synthesis and Properties of New Derivatives of 3-Benzylspiro[benzo[]quinazoline-5,1'-cycloheptane]-4(6)-one

Condensation of 3-benzyl-2-thioxo-2,3-dihydro-1-spiro[benzo[]quinazoline-5,1'-cycloheptane]-4(6)-one with 5,5-dialkyl-2-chloromethylbenzo[]quinazolines were used to synthesize dibenzo[]quinazoline compounds in which spiro[benzo[]quinazoline-5,1'-cycloheptane] in the second position is linked via a -SCH- linker to another benzo[]quinazoline molecule. The specified 2-thioxobenzo[]quinazoline, under similar conditions, upon reaction with methylene iodide, forms 2,2'-[(methylenebis(sulfandilyl))]bis[3-benzyl-3-spiro[benzo[]quinazoline-5,1'-cycloheptane]]-4(6)-one. A transition was made from the starting benzo[]quinazoline to the 2-hydrozimoderivative, which is cleaved in the presence of caustic potash to form 3-benzyl-3-spiro[benzo[]quinazoline-5,1'-cycloheptane]-4(6)-one. Based on the 2-hydrozimo derivative, hydrazone, thiosemicarbazide, and 4-benzyl-4-spiro[benzo[][1,2,4]triazolo[4,3-]quinazoline-6,1'-cycloheptanoenes] have been synthesized. Condensation of 4-benzyl-1-mercapto-4-spiro[benzo[][1,2,4]triazolo[4,3-]quinazoline-6,1'-cycloheptane]-5(7)-one with alkyl halides 1-sulfanyl-substituted triazolobenzo[]quinazoline derivatives of various structures were obtained. The antibacterial properties of the synthesized compounds were studied.