Synthesis and antimicrobial agents of thiazolidinone derivatives from benzocyclohepetenone

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A series of benzosuberone coupled piperazin‐1‐yl thiazolidin‐4‐one derivatives 6a‐j were synthesized from 3‐(2‐[9‐chloro‐2,3‐dimethyl‐6,7‐dihydro‐5 H ‐benzo[7]annulen‐8‐yl]‐4‐oxothiazolidin‐3‐yl)propanoic acid ( 4 ) and substituted piperazines/secondary amines 5a‐j using 1‐hydroxy benzotriazole, 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride and triethyl amine in good yields and their structures were characterized by 1 H NMR, 13 C NMR, IR, and Mass spectra. The newly synthesized compounds were evaluated for their antimicrobial activity against bacterial strains and a fungal strain. Compounds 6f and 6g were indicated promising and broad spectrum antibacterial activity.