Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment

By reacting the previously synthesized 4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carboxylic acid chloride with hydrazine hydrate a symmetrically substituted diacylhydrazine was synthesized, cyclized with phosphorus oxychloride to 2,5-bis-(4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-yl)-1,3,4-oxadiazole. For the synthesis of unsymmetrically 2,5-disubstituted 1,3,4-oxadiazoles, the condensation reaction of the above mantione acid chloride with various hydrazides was carried out, and the subsequent cyclization of the resulting diacyl-substituted hydrazines under action of phosphorus oxychloride. The antiarrhythmic properties of the synthesized compounds were studied.