Synthesis reveals antihypoxic properties of new 1,4-benzodioxanil-1,3,4-oxadiazole derivatives, indicating potential therapeutic uses.
Condensation of previously synthesized 1,4-benzodioxane-2-carboxylic acid hydrazide with chloranhydrides of various arylcycloalkane-, as well as aerylterrahydropyrancarboxylic acids substituted in the aromatic ring, gave N,N′-diacyl-substituted hydrazines, which are cyclized under the action of phosphorus oxychloride to the corresponding 1,3,4-oxadiazolebenzodioxanes. The antihypoxic properties of the synthesized compounds were studied.
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S. O. Vartanyan (2025) studied this question.
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