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November 28, 2025Journal of Psychopharmacology

Effects of cannabidiol on behavioral and psychological symptoms of vascular dementia: A randomized, double-blind, placebo-controlled clinical trial

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Authors

RPRebeca Mendes P. PessoaAZAntonio Waldo ZuardiRFRui Kleber V Martins Filho

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Overview

Randomized clinical trial found cannabidiol reduces behavioral symptoms in vascular dementia, suggesting its potential therapeutic role.

Key Points

  • CBD demonstrated significant reductions in behavioral symptoms in vascular dementia, indicating its potential efficacy.
  • Primary outcome measures showed reduced scores on behavioral assessments following cannabidiol treatment.
  • This double-blind, placebo-controlled trial involved 30 participants and utilized the Mini-Mental State Examination for cognitive evaluation.
  • The findings support cannabidiol's tolerability and safety, warranting further investigation into its therapeutic applications.

Cite This Study

Pessoa et al. (2025) studied this question.

synapsesocial.com/papers/6928f106a65b730b9ea79ac9https://doi.org/10.1177/02698811251390974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of cannabidiol on behavioral and psychological symptoms of vascular dementia: A randomized, double-blind, placebo-controlled clinical trial2025
  2. 2Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial2014 · 366 citations
  3. 3Cannabinoids for Behavioral Symptoms in Dementia: An Overview2024 · 6 citations
  4. 4Can cannabinoids alleviate behavioral symptoms in older adults with dementia? A systematic review2025
  5. 5Treatment of neuropsychiatric symptoms in Alzheimer’s disease with a cannabis-based magistral formulation: An open-label prospective cohort study2024 · 2 citations