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November 28, 2025BMC Pregnancy and ChildbirthOpen Access

Melatonin supplementation and outcomes of assisted reproductive technology: a systematic review and meta-analysis

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Authors

HTHongying TangJHJie HaoBXBin Xu

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Overview

Systematic review shows melatonin supplementation improves oocyte quality in assisted reproductive technology, suggesting potential benefits in specific populations.

Key Points

  • Melatonin supplementation significantly improves the quality of oocytes and embryos in assisted reproductive technology.
  • The systematic review and meta-analysis included data from numerous clinical studies to assess outcomes like clinical pregnancy rates.
  • Results indicate that while melatonin benefits oocyte and embryo quality, it did not significantly enhance clinical pregnancy or live birth rates.
  • Cochrane Collaboration guidelines were followed to evaluate risks and analyze data via Mean Difference and other statistical methods.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/6928f106a65b730b9ea79c83https://doi.org/10.1186/s12884-025-08503-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Melatonin supplementation and outcomes of assisted reproductive technology: a systematic review and meta-analysis2025
  2. 2Melatonin improved the outcomes of women with ART: a systematic review and meta-analysis of randomized trials2025 · 5 citations
  3. 3Effects of Melatonin in Women with Polycystic Ovary Syndrome Undergoing ART: A Systematic Review2026
  4. 4Melatonin Supplementation Increases Oocyte Recovery and Quality Associated with Altered Follicular Steroidogenesis and Redox Status in Dairy Cows2026
  5. 5Autologous bone marrow mesenchymal stem cell mitochondrial transplantation in recurrent assisted reproductive technology failure: a randomized controlled trial2026