What does this research mean for the field?

Melatonin supplementation in dairy cows prior to ovum pick-up and during in vitro maturation improves oocyte recovery, quality, and embryo development by reducing oxidative stress and altering follicular steroidogenesis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the protective effects and molecular mechanisms of melatonin supplementation on oocyte recovery, quality, and embryonic development following ovum pick-up in dairy cows.

September 2, 2026AntioxidantsOpen Access

Melatonin Supplementation Increases Oocyte Recovery and Quality Associated with Altered Follicular Steroidogenesis and Redox Status in Dairy Cows

View Full Paper

Ask AI

Bookmark

Authors

WMWenkui Ma QCQianru Chen DYDepeng Yin

Discussion

Member takes

Overview

Experimental study shows that melatonin supplementation enhances oocyte quality and embryo development in dairy cows, highlighting its potential to counteract oxidative stress in assisted breeding.

Key Points

To investigate the protective effects and molecular mechanisms of melatonin supplementation on oocyte recovery, quality, and embryonic development following ovum pick-up in dairy cows.
Administered subcutaneous melatonin to donor dairy cows prior to ovum pick-up and analyzed oocyte grade distribution, follicular fluid metabolomics, and blastocyst transcriptomics.
Supplemented oocyte maturation media in vitro with 10−7 mol/L melatonin to assess cleavage rates, blastocyst development, intracellular reactive oxygen species, and transcriptomic pathway changes.
In vivo melatonin administration significantly increased the proportion of high-quality Grade A oocytes, decreased low-quality Grade D oocytes, attenuated systemic and local oxidative stress, and enriched follicular estrogen derivatives and glutathione pathways.
Transcriptomic profiling of blastocysts showed significant upregulation of steroidogenesis rate-limiting genes STAR and HMGCR, as well as pathways tied to AMPK, FoxO, autophagy, and reduced cellular senescence.
In vitro supplementation with 10−7 mol/L melatonin significantly improved cleavage and blastocyst rates, increased total blastocyst cell counts, and scavenged intracellular reactive oxygen species compared to control.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2eac562ede874ec748c https://doi.org/10.3390/antiox15091101

View Full Paper

Ask AI

Bookmark

September 2, 2026AntioxidantsOpen Access

Melatonin Supplementation Increases Oocyte Recovery and Quality Associated with Altered Follicular Steroidogenesis and Redox Status in Dairy Cows

View Full Paper

Ask AI

Bookmark

Authors

WMWenkui Ma QCQianru Chen DYDepeng Yin

Discussion

Member takes

Overview

Experimental study shows that melatonin supplementation enhances oocyte quality and embryo development in dairy cows, highlighting its potential to counteract oxidative stress in assisted breeding.

Key Points

To investigate the protective effects and molecular mechanisms of melatonin supplementation on oocyte recovery, quality, and embryonic development following ovum pick-up in dairy cows.
Administered subcutaneous melatonin to donor dairy cows prior to ovum pick-up and analyzed oocyte grade distribution, follicular fluid metabolomics, and blastocyst transcriptomics.
Supplemented oocyte maturation media in vitro with 10−7 mol/L melatonin to assess cleavage rates, blastocyst development, intracellular reactive oxygen species, and transcriptomic pathway changes.
In vivo melatonin administration significantly increased the proportion of high-quality Grade A oocytes, decreased low-quality Grade D oocytes, attenuated systemic and local oxidative stress, and enriched follicular estrogen derivatives and glutathione pathways.
Transcriptomic profiling of blastocysts showed significant upregulation of steroidogenesis rate-limiting genes STAR and HMGCR, as well as pathways tied to AMPK, FoxO, autophagy, and reduced cellular senescence.
In vitro supplementation with 10−7 mol/L melatonin significantly improved cleavage and blastocyst rates, increased total blastocyst cell counts, and scavenged intracellular reactive oxygen species compared to control.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2eac562ede874ec748c https://doi.org/10.3390/antiox15091101

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark