Bidirectional Mendelian Randomization and Multi-Omics Uncover Causal Serum Metabolites and Neuro-Related Mechanistic Pathways in Acute Myeloid Leukemia

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Discussion

Bidirectional Mendelian randomization uncovers causal serum metabolites and molecular pathways in AML, suggesting new therapeutic targets.

Causal relationships were established between serum metabolites and acute myeloid leukemia (AML).
Significant associations involved 23 metabolites with analysis methods including Mendelian randomization.
Metabolic pathway analysis highlighted key pathways such as calmodulin binding and neuroactive signaling.
These findings may enable novel therapeutic targets for AML precision medicine.

Ye et al. (2025) studied this question.

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Bidirectional Mendelian randomization uncovers causal serum metabolites and molecular pathways in AML, suggesting new therapeutic targets.