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This research aims to explore the multi-omics landscape of acute myeloid leukemia for improved diagnostic and treatment strategies.

December 8, 2025Blood

Beyond the genome: An integrated multi-omics approach to uncover histone ptm-driven metabolic and proteomic regulation in AML

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Integrated multi-omics reveals complex metabolic and proteomic regulation in AML, suggesting new treatment pathways.

This research aims to explore the multi-omics landscape of acute myeloid leukemia for improved diagnostic and treatment strategies.
Developed a multi-omics approach integrating histone epigenome, proteome, and metabolome from AML cell lines
Utilized mass-spectrometry to analyze molecular fractions from 18 AML genotypes
Applied a machine-learning based network inference algorithm to identify protein co-expression modules.
Characterized 99 functional protein co-expression modules linked to hPTMs and metabolites
Identified metabolites like 5'CMP and hPTMs such as H1K21Ac in correlation with the mito-AML phenotype
Revealed novel modules associated with UBTF tandem duplications and monosomy 7.

Vanessa Vermeirssen (2025) studied this question.

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