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November 28, 2025Journal of VirologyOpen Access

Direct airway delivery of a humanized anti-H7N9 neutralizing antibody broadly protects against divergent H7 influenza viruses in the mouse model

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Authors

WYWang YuXHXiaozheng HeJZJiangyan Zhao

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Overview

Passive administration of monoclonal antibodies improved therapeutic efficacy and prophylactic protection against viral infection in mice, suggesting an effective airway delivery method.

Key Points

  • Airway delivery of the humanized antibody provided broad prophylactic protection against divergent H7 influenza viruses.
  • Chi4B7 demonstrated enhanced therapeutic efficacy compared to systemic intraperitoneal administration in mice with viral infection.
  • Administration via the respiratory tract allowed for a reduced dose of antibodies while maintaining protection against acute respiratory distress syndrome.
  • Therapeutic protection was significantly improved with the intranasal delivery method, highlighting a new approach against avian influenza.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/6928f113a65b730b9ea79fb7https://doi.org/10.1128/jvi.01327-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct airway delivery of a humanized anti-H7N9 neutralizing antibody broadly protects against divergent H7 influenza viruses in the mouse model2025 · 1 citations
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  3. 3A neutralizing nanobody targeting a conserved lateral patch on HA1 confers protection against multiple H7 avian influenza viruses2026
  4. 4Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head2024 · 19 citations
  5. 5A pan-influenza monoclonal antibody neutralizes H5 strains and prophylactically protects through intranasal administration2024 · 27 citations