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November 28, 2025Cogent Food & AgricultureOpen Access

Antioxidant, anti-inflammatory and cytoprotective potential of enzymatic protein hydrolysate from Moringa oleifera Lam. leaves in lipopolysaccharide-stimulated RAW 264.7 macrophages

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Authors

SSSafiah SAAHOSOrathai SawatdichaikulTPThidarat Pantoa

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Overview

Enzymatic hydrolysis enhances antioxidant and anti-inflammatory activities in macrophages, indicating potential therapeutic use of Moringa Oleifera protein hydrolysates.

Key Points

  • Hydrolysates from Moringa Oleifera increased cell viability significantly during oxidative stress.
  • The optimal extraction utilized 0.5 M sodium hydroxide with a 1:5 w/v ratio, enhancing protein content.
  • Assessments included antioxidant activity via MTT assays, focusing on IL-6 production reduction.
  • Substantial cytoprotective effects from protein hydrolysates suggest therapeutic potential for inflammation-related diseases.

Cite This Study

SAAH et al. (2025) studied this question.

synapsesocial.com/papers/6928f126a65b730b9ea7a341https://doi.org/10.1080/23311932.2025.2591288
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antioxidant, anti-inflammatory and cytoprotective potential of enzymatic protein hydrolysate from <i>Moringa oleifera</i> Lam. leaves in lipopolysaccharide-stimulated RAW 264.7 macrophages2025
  2. 2Optimization of Moringa oleifera Lam. leaf hydrolysis for the release of bioactive di- and tripeptides with antioxidant and biostimulant potential2026
  3. 3Evaluation of Cytotoxicity and Acute Oral Toxicity of Saline Extract and Protein-Rich Fraction from Moringa oleifera Lam. Leaves2024 · 5 citations
  4. 4Polyphenol compounds of freeze-dried Moringa oleifera Lam pods and their anti-inflammatory effects on RAW 264.7 macrophages stimulated with lipopolysaccharide2024 · 2 citations
  5. 5In vitro multifunctional bioactive properties of Moringa stenopetala seed enzymatic protein hydrolysates2026