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November 28, 2025Parasitology ResearchOpen Access

Comparative histopathological and immunological analysis of LRV2-positive and LRV2-negative Leishmania tropica in a BALB/c mouse cutaneous leishmaniasis model

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Authors

MÖMustafa ÖZTATLICIHOHulya OztatliciSASüha Kenan Arserim

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Overview

Comparative analysis of immune responses highlights oxidative stress in Leishmania tropica infections, impacting inflammation.

Key Points

  • Oxidative stress and inflammation were significant markers in Leishmania tropica infections in mice.
  • IL-6 levels were significantly elevated in both LRV2-positive and negative groups compared to controls.
  • Observational analysis utilized immunohistochemistry and qPCR to assess biomarkers and tissue responses.
  • The study indicates that while cytokine production remains unchanged, LRV2 enhances oxidative stress levels in tissues.

Cite This Study

ÖZTATLICI et al. (2025) studied this question.

synapsesocial.com/papers/6928f126a65b730b9ea7a3aahttps://doi.org/10.1007/s00436-025-08562-5
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