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December 10, 2025PathogensOpen Access

Leishmaniavirus Type 1 Enhances In Vitro Infectivity and Modulates the Immune Response to Leishmania (Viannia) Isolates

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Authors

AFA. FongVPVanessa PinedaJCJosé E. Calzada

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Overview

In vitro study shows LRV-1 enhances infectivity and alters cytokine profiles in Leishmania isolates, suggesting implications for treatment.

Key Points

  • The aim is to evaluate the effects of Leishmania RNA virus 1 on infectivity and immune responses in Panamanian Leishmania isolates.
  • Infectivity assessed using U937 macrophages and measuring the infectivity index at 24, 48, and 72 hours.
  • Cytokine levels for TNF-α, IL-1β, IL-6, and IL-17 quantified using flow cytometry and ELISA.
  • Comparison made between LRV-1-positive and LRV-1-negative isolates of Leishmania.
  • LRV-1+ isolates showed significantly higher infectivity at 48 and 72 hours compared to LRV-1− isolates.
  • Cytokine analysis indicated elevated levels of TNF-α and IL-1β in LRV-1+ isolates.
  • Reduced IFN-γ levels were observed in LRV-1+ isolates, while levels of IL-4, IL-6, IL-10, and IL-17 did not differ significantly.

Cite This Study

Fong et al. (2025) studied this question.

synapsesocial.com/papers/69401b3d2d562116f28f81a6https://doi.org/10.3390/pathogens14121263
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