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November 28, 2025ObesityOpen Access

Sex‐Specific Subcutaneous Adipose Tissue Transcriptome in Obesity: Insights From Monozygotic Twin Pairs Discordant for BMI

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Authors

HHHanna HaltiaMMMaheswary MuniandySHSini Heinonen

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Implication

Observational analysis revealed sex differences in adipose tissue gene expression in monozygotic twins, indicating obesity impacts metabolic health differently in males and females.

Key Points

  • Higher obesity-related inflammation was linked to insulin sensitivity variations in women, emphasizing sex differences.
  • RNA sequencing identified distinct gene expression patterns in subcutaneous adipose tissue across monozygotic twins and obesity levels.
  • Analysis highlighted the unique role of sex in adipose tissue's transcriptional response to obesity, especially regarding fatty acid metabolism.
  • Findings suggest biological sex plays a critical part in metabolic health and obesity response mechanisms, meriting further investigation.

Cite This Study

Haltia et al. (2025) studied this question.

synapsesocial.com/papers/6928f126a65b730b9ea7a4bfhttps://doi.org/10.1002/oby.70078
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex‐Specific Subcutaneous Adipose Tissue Transcriptome in Obesity: Insights From Monozygotic Twin Pairs Discordant for BMI2025 · 1 citations
  2. 2Transcriptomic landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue2024
  3. 3Sex-Specific Adipose Transcriptomic Reprogramming Drives Early Inter-Organ Remodeling in Heart and Liver Under Nutrient Excess2026
  4. 4Sex-specific Association Between Adipose Tissue Inflammation and Vascular and Metabolic Complications of Obesity2023 · 33 citations
  5. 5Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications2014 · 194 citations