Why the study?
Adipose tissue inflammation predisposes to insulin resistance and metabolic syndrome in obesity, but its sex-specific associations with metabolic and atherosclerotic complications remain to be fully defined.
Is adipose tissue inflammation associated with metabolic and atherosclerotic complications of obesity in a sex-specific manner in adults with BMI ≥ 27 kg/m2?
Population
302 adult subjects with a BMI ≥ 27 kg/m2
Comparison
Sex-specific associations of adipose tissue inflammation parameters
Design
Cross-sectional cohort study
Key result
Adipose tissue inflammation and adipocyte size were associated with metabolic syndrome and insulin resistance, but not carotid atherosclerosis, with stronger associations observed in men.
Authors
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AT inflammation links more to metabolic than atherosclerotic complications of obesity, stronger in men; leaves open causal roles and targeted interventions.
Cross-Sectional (n=302)
No
Is adipose tissue inflammation associated with metabolic and atherosclerotic complications of obesity in a sex-specific manner in adults with BMI ≥ 27 kg/m2?
Inflammation in abdominal subcutaneous adipose tissue is more strongly related to metabolic than atherosclerotic complications of obesity, with these associations being significantly more pronounced in men.
Cossins et al. (2023) conducted a cross-sectional in Obesity (n=302). Adipose tissue inflammation and adipocyte size was evaluated on Metabolic syndrome, insulin resistance, and carotid atherosclerotic plaques. Adipose tissue inflammation and adipocyte size were associated with metabolic syndrome and insulin resistance, but not carotid atherosclerosis, with stronger associations observed in men.
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