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June 20, 2008Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

An inflamed adipose phenotype was associated with higher HOMA-IR (5.5±4.5 vs 2.6±1.9, P=0.002) and impaired endothelium-dependent flow-mediated vasodilation (8.5±4.4% vs 10.8±3.8%, P<0.05) compared to noninflamed adipose architecture.

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Why the study?

Is adipose macrophage infiltration associated with insulin resistance and vascular endothelial dysfunction in obese subjects?

Population

n=77 obese subjects (BMI ≥30 kg/m²)

Comparison

Inflamed adipose phenotype characterized by… vs Quiescent noninflamed adipose architecture

Design

Cross-sectional

Authors

CACaroline M. ApovianSBSherman BigorniaMMMelanie M. Mott

Discussion

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Overview

Adipose inflammation may mark higher cardiometabolic risk in obesity; hypothesis-generating and should not yet change practice.

Structured PICO

Is adipose macrophage infiltration associated with insulin resistance and vascular endothelial dysfunction in obese subjects?

P
Population
n=77 obese subjects (BMI ≥30 kg/m²)
I
Intervention
Inflamed adipose phenotype characterized by tissue macrophage accumulation in crown-like structures
C
Comparator
Quiescent noninflamed adipose architecture
O
Outcome
Insulin resistance (HOMA-IR) and endothelium-dependent flow-mediated vasodilationsurrogate

Proinflammatory changes in adipose tissue are associated with systemic arterial dysfunction and insulin resistance in obese subjects, suggesting a link to increased cardiovascular risk.

Cite This Study

Apovian et al. (2008) studied this question.

synapsesocial.com/papers/6a70157378a11c550e09e2fahttps://doi.org/10.1161/atvbaha.108.170316
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