Key result
Higher pro-inflammatory M1-like macrophages in adipose tissue linked to greater insulin resistance.
Why the study?
A detailed characterization of pro- and anti-inflammatory adipose tissue macrophages in human obesity and their distribution in visceral and subcutaneous adipose depots was lacking.
Population
Humans with obesity providing subcutaneous and visceral adipose tissue samples
Comparison
Pro-inflammatory M1-like vs anti-inflammatory M2-like adipose tissue macrophages
Design
Observational surface proteome screening study
Authors
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Characterizes human ATM subsets across depots; leaves open their role in insulin resistance and need for functional validation.
Observational
Pro-inflammatory M1-like macrophages in both subcutaneous and visceral adipose tissue are positively associated with insulin resistance in human obesity.
Strand et al. (2022) conducted an observational in Obesity-induced insulin resistance. Pro-inflammatory M1-like macrophages was evaluated on Insulin resistance (HOMA-IR). A relative increase in pro-inflammatory M1-like macrophages in both subcutaneous and visceral adipose tissue was positively associated with insulin resistance assessed by HOMA-IR.
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