Key result
Adipose inflammation is associated with increased systemic inflammation, reduced insulin sensitivity, and reduced skeletal muscle mitochondrial respiration in obesity.
Why the study?
Adipose inflammation is proposed to be at the nexus of the systemic inflammation and metabolic derangements associated with obesity.
Observational
Adipose tissue inflammation is linked to systemic metabolic derangements in obesity, including insulin resistance and reduced mitochondrial respiration.
Highlights a potential mechanistic link between fat inflammation and systemic metabolic dysfunction; leaves open whether targeting adipose tissue directly.
Adipose inflammation is proposed to be at the nexus of the systemic inflammation and metabolic derangements associated with obesity. The present study provides evidence to support adipose inflammation as a central feature of the pathophysiology of obesity. Adipose inflammation is associated with systemic and peripheral metabolic derangements, including increased systemic inflammation, reduced insulin sensitivity, and reduced skeletal muscle mitochondrial respiration.
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Kunz et al. (2021) conducted an observational in obesity. Adipose inflammation was evaluated on systemic inflammation, insulin sensitivity, and skeletal muscle mitochondrial respiration. Adipose inflammation is associated with increased systemic inflammation, reduced insulin sensitivity, and reduced skeletal muscle mitochondrial respiration in obesity.
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