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November 30, 2025AJP Cell PhysiologyOpen Access

In vivo inhibition of miR-125b-5p modulates monocyte trafficking through the CCR7 receptor and reduces atherosclerosis

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Authors

AMAdrián MallénNRNoemi RotllanRGRaquel Griñán

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Overview

Observational analysis shows inhibition of mir-125b-5p reduces atherosclerosis progression in mice, indicating its role in monocyte trafficking and inflammation.

Key Points

  • Atherosclerosis progression was reduced through the inhibition of mir-125b-5p, impacting inflammation.
  • Treatment with the antagomiR-125b led to decreased plaque size and increased M2 macrophages.
  • Evaluation using ApoE -/- mice fed a high-fat diet showed significant effects on plaque progression and macrophage activity.
  • Targeting mir-125b-5p may provide a potential therapeutic strategy for coronary artery disease.

Cite This Study

Mallén et al. (2025) studied this question.

synapsesocial.com/papers/692b94261d383f2b2a378361https://doi.org/10.1152/ajpcell.00242.2025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vivo inhibition of miR-125b-5p modulates monocyte trafficking through the CCR7 receptor and reduces atherosclerosis2025
  2. 2In vivo inhibition of miR-125b modulates monocyte trafficking through the CCR7 receptor and attenuates atherosclerosis2024
  3. 3microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression2024 · 5 citations
  4. 4Upregulation of MicroRNA-125b Leads to the Resistance to Inflammatory Injury in Endothelial Progenitor Cells2020 · 3 citations
  5. 5Expression Analysis of <i>miR-20a-5p</i>, <i>miR-124-3P, miR-125b-5p, Resistin</i>, <i>TLR4</i>, <i>CD36</i> and <i>TNF-α</i> relationship in blood mononuclear cells from patients with atherosclerosis.2025