What does this research mean for the field?

In patients with atherosclerosis, TLR4 and Resistin are upregulated, miR-20a is downregulated and inversely correlated with fasting blood glucose, and miR-125b serves as a potential diagnostic biomarker. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the correlation of specific microRNAs and inflammatory genes in blood mononuclear cells related to atherosclerosis.

April 24, 2026Open Access

Expression Analysis of miR-20a-5p, miR-124-3P, miR-125b-5p, Resistin, TLR4, CD36 and TNF-α relationship in blood mononuclear cells from patients with atherosclerosis.

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Authors

MSMaysam Mard SoltaniDezful University of Medical Sciences GBGhazaleh BagheriLorestan University of Medical Sciences GBGolnar BakhtyarLorestan University of Medical Sciences

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Implication

Analysis reveals correlations between microRNAs and inflammatory genes in atherosclerosis patients, suggesting new biomarkers.

Key Points

To evaluate the correlation of specific microRNAs and inflammatory genes in blood mononuclear cells related to atherosclerosis.
Evaluated gene levels in peripheral blood mononuclear cells from patients with angiography-proven atherosclerosis and healthy controls
Measured expression using real-time polymerase chain reaction
Analyzed the correlation between microRNAs and inflammatory genes
TLR4 and Resistin were upregulated in atherosclerosis patients compared to controls (p<0.05)
miR-20a was downregulated and inversely correlated with fasting blood glucose (p<0.05)
miR-125b levels may serve as a potential biomarker for atherosclerosis with an AUC of 0.74

Cite This Study

Soltani et al. (2025) studied this question.

synapsesocial.com/papers/69eb0961553a5433e34b3d3a https://doi.org/10.22088/ijmcm.bums.14.4.1014

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Expression Analysis of miR-20a-5p, miR-124-3P, miR-125b-5p, Resistin, TLR4, CD36 and TNF-α relationship in blood mononuclear cells from patients with atherosclerosis.

Discussion

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Implication

Key Points

Cite This Study

Expression Analysis of miR-20a-5p, miR-124-3P, miR-125b-5p, Resistin, TLR4, CD36 and TNF-α relationship in blood mononuclear cells from patients with atherosclerosis.

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Key Points

Cite This Study

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