What question did this study set out to answer?

This research aims to explore the expression levels of miR-124-3p and miR-133a-3p and their relationship with S100A4-positive vascular smooth muscle cells in atherosclerosis.

March 3, 2026The Indian Journal of Medical ResearchOpen Access

Evaluation of miRNA-133a-3p and miRNA-124-3p expression in atherosclerosis using real-time PCR and immunohistochemical methods

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Authors

NENazan Eras LBLeyla BaharMersin Üniversitesi ABAbdülkadir BilgiçMersin Üniversitesi

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Evaluation discovers downregulation of specific miRNAs linked to inflammatory changes in atherosclerosis.

Key Points

This research aims to explore the expression levels of miR-124-3p and miR-133a-3p and their relationship with S100A4-positive vascular smooth muscle cells in atherosclerosis.
Collected tissue samples from 25 atherosclerosis patients undergoing coronary artery bypass graft surgery
Compared atherosclerotic aortic tissues with IMA tissues as controls
Assessed miRNA expression using reverse transcription polymerase chain reaction (RT-PCR)
Conducted immunohistochemical staining for S100A4 protein
Significantly decreased expression of miR-133a-3p and miR-124-3p in atherosclerosis compared to controls
Increased S100A4 protein immunoreactivity in atherosclerosis tissues

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Eras et al. (2026) studied this question.

synapsesocial.com/papers/69a67ec3f353c071a6f0a3b2 https://doi.org/10.25259/ijmr_1883_2025

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Evaluation of miRNA-133a-3p and miRNA-124-3p expression in atherosclerosis using real-time PCR and immunohistochemical methods

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Cite This Study

Evaluation of miRNA-133a-3p and miRNA-124-3p expression in atherosclerosis using real-time PCR and immunohistochemical methods

Discussion

Member takes

Implication

Key Points

Cite This Study

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