Key result
Elevated miR-183-5p is linked to atherosclerosis and promotes VSMC proliferation and migration.
Why the study?
Atherosclerosis is a multifactorial chronic disease involving vascular smooth muscle cells, and the clinical value of miR-183-5p in AS patients and its effects on VSMCs were unclear.
Does miR-183-5p serve as a diagnostic biomarker for atherosclerosis and regulate vascular smooth muscle cell growth?
Population
Atherosclerosis patients and healthy controls
Comparison
miR-183-5p expression in AS patients vs healthy controls; overexpression vs control in VSMCs
Design
Case-control study with in vitro assays
Authors
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miR-183-5p may aid AS diagnosis; hypothesis-generating for VSMC-targeted effects, needs prospective validation.
Case-Control
Does miR-183-5p serve as a diagnostic biomarker for atherosclerosis and regulate vascular smooth muscle cell growth?
MiR-183-5p is upregulated in atherosclerosis, correlates with disease markers, and promotes vascular smooth muscle cell proliferation and migration, suggesting potential as a diagnostic biomarker.
Sun et al. (2020) conducted a case-control in Atherosclerosis. miR-183-5p vs. Healthy group was evaluated on Atherosclerosis detection. MiR-183-5p was highly expressed in atherosclerosis patients compared with healthy controls, demonstrating potential as a diagnostic biomarker and promoting VSMC proliferation and migration.
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