Why the study?
The study was conducted to evaluate the clinical value and expression level of miR-455-5p in atherosclerosis patients and analyze its regulatory effect on vascular smooth muscle cell proliferation and migration.
Does miR-455-5p serve as a diagnostic biomarker for atherosclerosis and regulate VSMC proliferation and migration?
Does miR-455-5p serve as a diagnostic biomarker for atherosclerosis and regulate VSMC proliferation and migration?
MiR-455-5p is a potential diagnostic biomarker for atherosclerosis and inhibits vascular smooth muscle cell proliferation and migration by targeting SOCS3.
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Hypothesis-generating for miR-455-5p in atherosclerosis; human validation required before clinical consideration.
Background: This study discussed the clinical value and expression level of miR-455-5p in atherosclerosis (AS) patients. Meanwhile, its regulatory effect on the proliferation and migration of vascular smooth muscle cells (VSMCs) was further analyzed. Materials & methods: Clinical experiments were detected by quantitative real-time PCR and receiver operating characteristic. Cell experiments were detected by CCK-8, transwell and luciferase reporter gene assay. Results: miR-455-5p was low expressed in AS patients and had diagnostic value to distinguish AS patients from healthy controls. MiR-455-5p inhibited the proliferation and migration of VSMCs. SOCS3 was the target gene of miR-455-5p. Conclusion: MiR-455-5p may be used as a potential diagnostic biomarker for AS. MiR-455-5p may inhibit the proliferation and migration of VSMCs through targeting SOCS3.
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Zhang et al. (2021) studied this question.
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