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June 28, 2026Journal of Cardiothoracic SurgeryOpen Access

MicroRNA-425-5p as a diagnostic biomarker and ox-LDL-induced VSMC regulator in atherosclerosis

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Authors

JCJinguang ChenBLBin LinZZZhenbin Zhan

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Overview

Randomized trial evaluates miR-425-5p as a diagnostic biomarker for atherosclerosis, suggesting its role in VSMC regulation.

Key Points

  • This research investigates the expression patterns of miR-425-5p and its clinical relevance in atherosclerosis.
  • Evaluated 131 atherosclerosis patients and 112 controls.
  • Quantified serum miR-425-5p and KLF7 levels using RT-qPCR and assessed diagnostic value through ROC analysis.
  • Developed an in vitro model using ox-LDL-stimulated HVSMC cells to analyze cell viability, apoptosis, inflammation, and migration.
  • miR-425-5p was upregulated in atherosclerosis patients, showing 85.50% sensitivity and 85.71% specificity for diagnosis.
  • Positive correlation of serum miR-425-5p with CIMT, TG, LDL-C, and negative correlation with HDL-C was identified.
  • Ox-LDL-induced HVSMC dysfunction was mitigated by miR-425-5p inhibition and further reduced with KLF7 knockdown.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a40b9f361bb0a67205c608fhttps://doi.org/10.1186/s13019-026-04307-2
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