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August 2, 2026Journal of Biochemical and Molecular Toxicology

Hsacirc₀044097 Serves as a Promising Biomarker of Atherosclerosis and Its Effects on Vascular Smooth Cell Proliferation and Migration

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Authors

CRCencen RenYJYungen Jiao

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Overview

Randomized trial investigates hsa_circ_0044097's role in vascular smooth muscle cells, indicating its biomarker potential for atherosclerosis.

Key Points

  • The study aims to evaluate the potential of hsa_circ_0044097 as a biomarker for atherosclerosis and its effects on vascular smooth muscle cell behavior.
  • mRNA expressions of hsa_circ_0044097 and miR-3918 were measured using RT-qPCR.
  • Proliferation and migration of HASMC cells were assessed using CCK-8 and transwell assays.
  • The relationship between hsa_circ_0044097 and miR-3918 was verified through dual luciferase reporter assay and correlation analysis.
  • Hsa_circ_0044097 levels were lower in atherosclerosis patients' serum and in HASMCs stimulated by ox-LDL.
  • Overexpression of hsa_circ_0044097 led to decreased inflammatory factor levels and reduced VSMC proliferation and migration.
  • Hsa_circ_0044097 serves as a biomarker for diagnosing atherosclerosis and predicting major adverse cardiovascular events.

Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeb201b0468a7eeab4038https://doi.org/10.1002/jbt.71031
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