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June 9, 2023Shock

Circ_0091822 knockdown inhibits ox-LDL-induced VSMC proliferation, invasion, and migration via the miR-339-5p/BOP1/Wnt/β-catenin pathway.

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Why the study?

Whether circ_0091822 mediates vascular smooth muscle cells function to regulate atherosclerosis process is unclear.

Does circ_0091822 knockdown prevent ox-LDL-induced proliferation, invasion, and migration in vascular smooth muscle cells?

Population

Vascular smooth muscle cells treated with oxidized low-density lipoprotein and serum from atherosclerosis patients

Comparison

Circ_0091822 knockdown vs control under ox-LDL treatment

Design

Preclinical cell model study

Key result

Circ_0091822 knockdown inhibited ox-LDL-induced vascular smooth muscle cell proliferation, invasion, and migration by modulating the miR-339-5p/BOP1/Wnt/β-catenin pathway.

Authors

HSHu SunXinjiang Medical UniversityXHXiaoyuan HuangXinjiang Medical UniversitySHShichai HongFujian Medical University

Discussion

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Member takes

Overview

Hypothesis-generating in ox-LDL VSMC models; leaves open circ_0091822 as atherosclerosis target pending in vivo data.

Structured PICO

Does circ_0091822 knockdown prevent ox-LDL-induced proliferation, invasion, and migration in vascular smooth muscle cells?

P
Population
Vascular smooth muscle cells (VSMCs) treated with oxidized low-density lipoprotein (ox-LDL) to construct atherosclerosis cell models, and serum from atherosclerosis patients
I
Intervention
Circ_0091822 knockdown
C
Comparator
Control (ox-LDL treatment without circ_0091822 knockdown)
O
Outcome
Vascular smooth muscle cells proliferation, invasion, and migrationsurrogate

Circ_0091822 facilitates ox-LDL-induced VSMC proliferation, invasion, and migration, highlighting it as a potential therapeutic target for atherosclerosis.

Cite This Study

Sun et al. (2023) studied Atherosclerosis. circ_0091822 knockdown vs. Control was evaluated on Vascular smooth muscle cell proliferation, invasion, and migration. Circ_0091822 knockdown inhibited ox-LDL-induced vascular smooth muscle cell proliferation, invasion, and migration by modulating the miR-339-5p/BOP1/Wnt/β-catenin pathway.

synapsesocial.com/papers/6aab8216e1eb48dc6be708eahttps://doi.org/10.1097/shk.0000000000002163
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circ_0093887 upregulates CCND2 and SUCNR1 to inhibit the ox‐LDL‐induced endothelial dysfunction in atherosclerosis by functioning as a miR‐876‐3p sponge2021 · 20 citations
  2. 2Circular RNA circ_0008896 contributes to oxidized low-density lipoprotein-induced aortic endothelial cell injury via targeting miR-188-3p/NOD2 axis2023 · 6 citations
  3. 3Circ_0002984 induces proliferation, migration and inflammation response of VSMCs induced by ox‐LDL through miR‑326‐3p/VAMP3 axis in atherosclerosis2021 · 42 citations
  4. 4Knockdown of circ_0003204 alleviates oxidative low-density lipoprotein-induced human umbilical vein endothelial cells injury: Circulating RNAs could explain atherosclerosis disease progression2021 · 16 citations
  5. 5Hsa-circ_0010283 Regulates Oxidized Low-Density Lipoprotein-Induced Proliferation and Migration of Vascular Smooth Muscle Cells by Targeting the miR-133a-3p/Pregnancy-Associated Plasma Protein A Axis2020 · 18 citations