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June 25, 2021Journal of Cellular and Molecular MedicineOpen Access

Circ₀002984 induces proliferation, migration and inflammation response of VSMCs induced by ox‐LDL through miR‑326‐3p/VAMP3 axis in atherosclerosis

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Key result

Knockdown of circ_0002984 suppresses ox-LDL-induced VSMC proliferation, migration, and inflammation via the miR-326-3p/VAMP3 axis.

Why the study?

The effect of circ_0002984 on vascular smooth muscle cells in atherosclerosis was previously unknown.

Population

Serum of atherosclerosis patients and ox-LDL-incubated VSMCs

Comparison

Modulation of circ_0002984, miR-326-3p, and VAMP3 expression

Design

Preclinical experimental study

Authors

RLRuogu LiQJQiliang JiangYZYue Zheng

Discussion

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Overview

Should not yet alter clinical management of atherosclerosis; hypothesis-generating for circRNA roles in VSMC dysfunction.

Structured PICO

P
Population
Serum of atherosclerosis patients and vascular smooth muscle cells (VSMCs) incubated by oxidized low-density lipoprotein (ox-LDL)
I
Intervention
Modulation (knockdown or overexpression) of circ_0002984, miR-326-3p, and VAMP3
O
Outcome
VSMC viability, cell cycle distribution, migration capacity, and inflammation (TNF-α and IL-6 levels)surrogate

circ_0002984 promotes proliferation, migration, and inflammation in ox-LDL-treated VSMCs via the miR-326-3p/VAMP3 axis, highlighting a potential therapeutic target for atherosclerosis.

Cite This Study

Li et al. (2021) studied Atherosclerosis. circ_0002984 knockdown/overexpression vs. control VSMCs was evaluated on VSMC proliferation, migration, and inflammation. Knockdown of circ_0002984 suppressed ox-LDL-induced VSMC proliferation, migration, and inflammation by modulating the miR-326-3p/VAMP3 axis.

synapsesocial.com/papers/6ab088772163372aab03bcechttps://doi.org/10.1111/jcmm.16734
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Also Consider

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  1. 1circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells2019 · 179 citations
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