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November 5, 2020Circulation JournalOpen Access

Knockdown of circ_0010283 suppressed ox-LDL-induced proliferation, migration, and invasion in human vascular smooth muscle cells by modulating the miR-133a-3p/PAPPA pathway.

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Population

Serum samples from atherosclerosis patients and oxidized low-density lipoprotein-treated human vascular…

Design

Preclinical

Key result

Knockdown of circ_0010283 suppressed ox-LDL-induced proliferation, migration, and invasion in human vascular smooth muscle cells by modulating the miR-133a-3p/PAPPA pathway.

Authors

ZFZibo FengYZYoupeng ZhuJZJing Zhang

Discussion

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Overview

circ_0010283 may regulate VSMC proliferation in atherosclerosis models; leaves open therapeutic relevance pending in vivo studies.

Structured PICO

P
Population
36 patients with atherosclerosis and 36 paired normal volunteers whose serum samples were analyzed alongside in vitro experiments on human vascular smooth muscle cells.
I
Intervention
circ_0010283 knockdown
O
Outcome
Cell proliferation, apoptosis, migration, and invasionsurrogate

Main Result

p-value: p=<0.05

circ_0010283 promotes ox-LDL-induced dysfunction of human vascular smooth muscle cells via the miR-133a-3p/PAPPA axis, highlighting a potential therapeutic target for atherosclerosis.

Cite This Study

Feng et al. (2020) studied Atherosclerosis (n=72). circ_0010283 knockdown vs. Negative control (si-NC) was evaluated on Cell proliferation, migration, invasion, and apoptosis (p=<0.05). Knockdown of circ_0010283 suppressed ox-LDL-induced proliferation, migration, and invasion in human vascular smooth muscle cells by modulating the miR-133a-3p/PAPPA pathway.

synapsesocial.com/papers/6ab3592dce6161d3ec7231d1https://doi.org/10.1253/circj.cj-20-0345
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circ-CHFR modulates the proliferation, migration, and invasion of ox-LDL-induced human aorta vascular smooth muscle cells through the miR-214-3p/PAPPA axis2021 · 15 citations
  2. 2CIRC_0091822 CONTRIBUTES TO THE PROLIFERATION, INVASION, AND MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS UNDER OXIDIZED LOW-DENSITY LIPOPROTEIN TREATMENT2023 · 1 citations
  3. 3Exosomes Promote Atherosclerosis Progression by Regulating Circ_100696/miR-503-5p/PAPPA Axis-Mediated Vascular Smooth Muscle Cells Proliferation and Migration2023 · 14 citations
  4. 4Circ_0002984 induces proliferation, migration and inflammation response of VSMCs induced by ox‐LDL through miR‑326‐3p/VAMP3 axis in atherosclerosis2021 · 42 citations
  5. 5Oxygenized Low-Density Lipoprotein-Induced ASMC Dysregulation Depends on circ_0000345-Mediated Regulatory Mechanism2022 · 3 citations