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November 26, 2021Clinical Hemorheology and Microcirculation

Circ-CHFR modulates the proliferation, migration, and invasion of ox-LDL-induced human aorta vascular smooth muscle cells through the miR-214-3p/PAPPA axis

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Key result

Downregulation of circ-CHFR inhibited the proliferation, migration, and invasion of ox-LDL-exposed human aorta vascular smooth muscle cells by acting as a miR-214-3p sponge to regulate PAPPA.

Population

Human aorta vascular smooth muscle cells (HA-VSMCs) exposed to oxidized low-density lipoprotein (ox-LDL)

Design

Preclinical

Authors

QLQianqian LuYLYing LiJLJiaping Lou

Discussion

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Overview

circ-CHFR may promote atherosclerosis in VSMCs; leaves open clinical relevance without in vivo or human data.

Structured PICO

P
Population
Human aorta vascular smooth muscle cells (HA-VSMCs) exposed to oxidized low-density lipoprotein (ox-LDL)
I
Intervention
Downregulation of circ-CHFR or overexpression of miR-214-3p
O
Outcome
Cell proliferation, migration, and invasion capabilitiessurrogate

The circ-CHFR/miR-214-3p/PAPPA axis regulates ox-LDL-induced proliferation, migration, and invasion in human aorta vascular smooth muscle cells, highlighting a potential therapeutic target for atherosclerosis.

Cite This Study

Lu et al. (2021) studied atherosclerosis. circ-CHFR downregulation vs. control was evaluated on Cell proliferation, migration, and invasion. Downregulation of circ-CHFR inhibited the proliferation, migration, and invasion of ox-LDL-exposed human aorta vascular smooth muscle cells by acting as a miR-214-3p sponge to regulate PAPPA.

synapsesocial.com/papers/6ab1d78db978dcf16985be72https://doi.org/10.3233/ch-211288
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hsa-circ_0010283 Regulates Oxidized Low-Density Lipoprotein-Induced Proliferation and Migration of Vascular Smooth Muscle Cells by Targeting the miR-133a-3p/Pregnancy-Associated Plasma Protein A Axis2020 · 18 citations
  2. 2Exosomes Promote Atherosclerosis Progression by Regulating Circ_100696/miR-503-5p/PAPPA Axis-Mediated Vascular Smooth Muscle Cells Proliferation and Migration2023 · 14 citations
  3. 3Oxygenized Low-Density Lipoprotein-Induced ASMC Dysregulation Depends on circ_0000345-Mediated Regulatory Mechanism2022 · 3 citations
  4. 4Circ_0002984 induces proliferation, migration and inflammation response of VSMCs induced by ox‐LDL through miR‑326‐3p/VAMP3 axis in atherosclerosis2021 · 42 citations
  5. 5Circ_CHMP5 aggravates oxidized low-density lipoprotein-induced damage to human umbilical vein endothelial cells through miR-516b-5p/TGFβR2 axis2023 · 10 citations